低密度脂蛋白胆固醇（LDL-C）被认为是有害的吗？

低密度脂蛋白胆固醇（LDL-C）主要由两种成分组成：大而轻的 LDL（lbLDL-C，或称为A型）和小而密的 LDL（sdLDL-C，或称为B型）。其中，sdLDL-C 通常被称为“坏”胆固醇。

你可以通过以下公式计算 sdLDL-C 的比例：

甘油三酯（TG） / 低密度脂蛋白胆固醇（LDL-C）

解读结果：

低于 1.1 的比率表明胆固醇水平良好。
相反，高于1.1 的比率则表明胆固醇水平不佳。

了解这些数值可以帮助你做出明智的胆固醇健康决策。

Is Low-Density Lipoprotein Cholesterol (LDL-C) Considered Unfavorable?

Low-Density Lipoprotein Cholesterol (LDL-C) consists of two main components: large buoyant LDL (lbLDL-C, or Pattern A) and small dense LDL (sdLDL-C, or Pattern B). Among these, sdLDL-C is often referred to as “bad” cholesterol.

You can determine the ratio of sdLDL-C using the following equation:

Triglycerides (TG) / Low-Density Lipoprotein Cholesterol (LDL-C)

Interpreting the results:

A ratio of less than 1.1 indicates a favorable cholesterol profile.
Conversely, a ratio greater than 1.1 suggests a less favorable cholesterol profile.

Understanding these values can help you make informed decisions about your cholesterol health.

REFERENCE

Triglyceride/low-density-lipoprotein cholesterol ration is the most valuable predictor for increased small, dense LDL in type 2 diabetes patients (Published 07 January 2022)

文章摘要

本文探讨了甘油三酯/低密度脂蛋白胆固醇（TG/LDL-C）比率与2型糖尿病患者小、致密低密度脂蛋白（sd-LDL）之间的关系。研究发现，TG/LDL-C比率是sd-LDL的可靠替代脂质标志物，优于非高密度脂蛋白胆固醇（non-HDL-C）在未接受他汀治疗的2型糖尿病患者中对sd-LDL水平的预测。

主要发现

TG/LDL-C比率与2型糖尿病患者的sd-LDL水平呈正相关。
对于未使用他汀的患者，TG/LDL-C比率的曲线下面积（AUC）高于non-HDL-C。
TG/LDL-C比率的最佳切割点为1.1（摩尔比），与他汀治疗无关。
在未使用他汀的患者中，TG/LDL-C比率的敏感性和特异性高于non-HDL-C。

结论

研究表明，TG/LDL-C比率是2型糖尿病患者sd-LDL水平的重要预测指标，可作为临床实践中sd-LDL的替代标志物。

TG/LDL-C比率的解读

TG/LDL-C比率被认为是2型糖尿病患者小、致密低密度脂蛋白（sd-LDL）水平的有价值预测指标。较低的TG/LDL-C比率通常被认为更好。

最佳切割点

根据研究，TG/LDL-C比率的最佳切割点为1.1（摩尔比），与他汀治疗无关。这意味着TG/LDL-C比率低于1.1与较低的sd-LDL水平相关，这是一种理想的情况。

理想的TG/LDL-C比率

良好的TG/LDL-C比率应为：

低于1.1（摩尔比），表明sd-LDL水平较低
较低的数值表示心血管疾病风险较低

需要注意的是，TG/LDL-C比率的解读应结合其他脂质谱和健康指标，并考虑个体患者的特征和病史。

Summary of the Article

The article discusses the relationship between the triglyceride/low-density-lipoprotein cholesterol (TG/LDL-C) ratio and small, dense low-density lipoprotein (sd-LDL) in type 2 diabetes patients. The study found that the TG/LDL-C ratio is a reliable surrogate lipid marker of sd-LDL and is superior to non–high-density-lipoprotein cholesterol (non–HDL-C) in predicting sd-LDL levels in type 2 diabetes patients not treated with statins.

Key Findings

The TG/LDL-C ratio correlated positively with sd-LDL levels in type 2 diabetes patients.
The area under the curve (AUC) for the TG/LDL-C ratio was higher than that for non–HDL-C in patients without statins.
The optimal cut-off point for the TG/LDL-C ratio for increased sd-LDL was 1.1 (molar ratio) regardless of statin treatment.
The sensitivity and specificity of the TG/LDL-C ratio were higher than those of non–HDL-C in patients without statins.

Conclusion

The study suggests that the TG/LDL-C ratio is a valuable predictor of sd-LDL levels in type 2 diabetes patients and may be used as a surrogate marker for sd-LDL in clinical practice.

Interpretation of the TG/LDL-C Ratio

The TG/LDL-C ratio is considered a valuable predictor of small, dense low-density lipoprotein (sd-LDL) levels in type 2 diabetes patients. A lower TG/LDL-C ratio is generally considered better.

Optimal Cut-off Point

According to the study, the optimal cut-off point for the TG/LDL-C ratio for increased sd-LDL is 1.1 (molar ratio) regardless of statin treatment. This means that a TG/LDL-C ratio below 1.1 is associated with lower sd-LDL levels, which is desirable.

What a Good TG/LDL-C Ratio Looks Like

A good TG/LDL-C ratio would be:

Less than 1.1 (molar ratio), indicating lower sd-LDL levels
Lower values indicating a lower risk of cardiovascular disease

It’s essential to note that the TG/LDL-C ratio should be interpreted in conjunction with other lipid profiles and health markers, as well as in the context of individual patient characteristics and medical history.

Samiux
二零二四年十月十三日，中国香港